Acetyl chloride undergoes nucleophilic substitution at a faster rate than methyl

Question

Acetyl chloride undergoes nucleophilic substitution at a faster rate than methyl acetate because: A) the ester is more sterically hindered than the acid chloride. B) the acid chloride is more sterically hindered than the ester. C) the methoxide is a better leaving group than chloride. D) esters hydrolyze faster than acid chlorides. E) chloride is a better leaving group than methoxide. Typically, amides will hydrolyze under _______ conditions than esters. A) milder B) more dilute C) more vigorous D) less vigorous E) more saline

Explanation / Answer

Acetyl chloride undergoes nucleophilic substitution at a faster rate than methyl acetate because

A. esters hydrolyze faster than acid chlorides.
B. the ester is more sterically hindered than the acid chloride
C. the acid chloride is more sterically hindered than the ester
D. the methoxide is a better leaving group than chloride
E. chloride is a better leaving group than methoxide-------------------answer

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Typically, amides will hydrolyze under ___________ conditions than esters

A) stronger -----------------ANSWER
B) more dilute
C) milder
D) less vigorous
E) more saline

The substrates are comparative alongside the "leaving group." The weaker the base, the better the leaving gathering. Chloride is an especially decent leaving bunch on the grounds that HCl is a solid corrosive. The methoxide particle is a poor leaving gathering; its basicity is on the request of that of the hydroxide particle. Steric deterrent ought not so much have an impact in this response. As expressed, the substrated are comparative and the geometry around the carbonyl carbon is trigonal planar.

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