Cardiac muscle is exquisitely sensitive to glucose and oxygen availability. Duri

Question

Cardiac muscle is exquisitely sensitive to glucose and oxygen availability. During times of oxygen deprivation, cardiac myocytes can switch from oxidative metabolism of glucose to anaerobic metabolism, to bide time until oxygen levels are restored. If glucose is theoretically metabolized once every 5 seconds, what will be the net energy production (in ATP equivalents) for a cardiac myocyte that begins aerobically metabolizing glucose for 20 seconds but then switches to anaerobic metabolism for the next minute due to a transient decrease in bloodoxygen levels? The answer is 176, but I do not know how to get it.

Explanation / Answer

During aerobic respiration total ATP produced per glucose is 38(2 from glycolysis, 2 from crebs cycle and 34 from electron transport system). So in 20 second 4 glucose will be used up for respiration and ATP produced will be 4*38=152. Now next minute ie for 60 seconds anaerobic respiration will be going on for 60/5 times is 12 times. Produced ATP is 12*2= 24

So total ATP produced = 152+24=176

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