Problem 7. An understanding of osmotic pressure is impor- tant in medicine. Cons

Question

Problem 7. An understanding of osmotic pressure is impor- tant in medicine. Consider the case reported by Steinmuller (1998) in the New England Journal of Medicine. A 5% solution of albumin was needed to infuse into a patient with kidney disease (renal insufficiency, No 5% solution was available, so the hospital pharmacy used 25% albumin diluted 1:4 with pure water. Injection of the solution into the patient caused renal failure. The albumin in a 25% albumin solution has an osmolarity of about 36 mosmol. Typically, such a solution also contains about 300 mosmol of other ions (see Problem 6) (a) Calculate the osmolarity of the solution injected into the patient.

Explanation / Answer

osmolarity of 25% albumin = 36 mosmol

osmolarity of other ions = 300 mosmol

osmolarity of the solution injected into the patient = 36 + 300

= 336 mosmol /L

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