Answer the following questions about Regulation of Microtubulue Dynamics -What a
ID: 57514 • Letter: A
Question
Answer the following questions about Regulation of Microtubulue Dynamics
-What are the primary signals?
-Which of the six types of receptors are involved?
-How is the signal transmitted into the cell?
-What are some signal transducing molecules?
-What are some effectors?
-What is the net result of pathway activity?
following link is kind of help full: http://www.cellsignal.com/contents/science-cst-pathways-cytoskeletal/regulation-of-microtubule-dynamics-signaling-pathway/pathways-micro?Ntk=Content&N=4294956305&Ntt=microtubules&fromPage=plp
Explanation / Answer
In the given link, primary signal is neurotrophins, and Wnt protein ligand Tyrosine kinase receptor is involved. G-protein coupled receptor is also involved. Autophosphorylation of tyrosine kinase receptor-----> transmits the signal to Akt-----> further signal is transferred to GSK-3Beta which is activated from MAP kinase pathway----> further transmits signal to MTOC Signal transducing molecules include the primary signal i.e neurotrophin and secondary signals like PIP3 which takes the signal further When the receptor detaches from the primary signal, it attaches to effector to take the pathway further. In this case effectors are stathmins, PIP3, Akt, Tau Tubulin undergoes various post translational modifications. These post translational modifications alter the binding of MT motors and other proteins. Overall they effect MT stability and dynamics.