Match the statement/descriptor listed in the left-hand column to the appropriate
ID: 58420 • Letter: M
Question
Match the statement/descriptor listed in the left-hand column to the appropriate inhibitor of skeletal muscle contraction listed in the right-hand column.
Botulinum Toxin
Curare
Nerve Gas or Pesticide Organophosphates
prevents ACh from having access to its receptors on the skeletal muscle motor end plate
paralyzes the skeletal muscle in its flaccid or 'limp' state even when ACh is present in the NMJ synapse
prevents release of acetylcholine (ACh) by somatic motor neuron
prevents normal breakdown of ACh in the NMJ synapse by inhibiting the AChEase enzyme tethered to the motor end plate of the muscle fiber
paralyzes the skeletal muscle in its contracted state
paralyzes the skeletal muscel in its flaccid or 'limp' state due to absence of NT in the NMJ synapse
1.Botulinum Toxin
2.Curare
3.Nerve Gas or Pesticide Organophosphates
Explanation / Answer
1) Botulinum Toxin: prevents release of acetylcholine (ACh) by somatic motor neuron and paralyzes the skeletal muscle in its flaccid or 'limp' state due to absence of NT in the NMJ synapse.
2) Curare: paralyzes the skeletal muscle in its contracted state, prevents ACh from having access to its receptors on the skeletal muscle motor end plate (Curare occupies ACh receptors).
3) Nerve Gas or Pesticide Organophosphates: prevents normal breakdown of ACh in the NMJ synapse by inhibiting the AChEase enzyme tethered to the motor end plate of the muscle fiber.paralyzes the skeletal muscle in its flaccid or 'limp' state even when ACh is present in the NMJ synapse (organophosphates inhibit AChE enzyme activity).