Problem 1: Using any technique and chemical reaction covered in CHE201 this seme
ID: 586858 • Letter: P
Question
Problem 1: Using any technique and chemical reaction covered in CHE201 this semester prepare compound B from 5mmoles of compound A. Please answer question 2 in part A.
Lab 10: Fall 2017-Planning an Organic chemistry lab experimen Due Week of Nov 27 before start of Lab final exam Name TA: Problem 1: Using any technique and chemical reaction(s) covered in CHE 201 this semester prepare compound B from 5 mmoles of compound A. Compound A is very expensive and your planned reaction needs to be efficient (90 % or higher yield) PART A: 13 points (replaces data sheet, note book, performance and lab report points) 1. Plan and show your planned synthetic scheme in th Properties Mol. weight form of a reaction e Proviae a aetailed procedure (Preparation, Purification Melting/Freezing Point & Analysis). 10 points 190.16 226.8 57 C 267 C 0.02 174 C 372 C 0.7 226.8 174 C 372 C 0.5 Boiling Point Solubility (grams in Solubility Solubility Procedure should include quantities (with correct stoichiometry) of chemicals required. 1. 2. Mention all the techniques that will be required. 10 ml hot water) 3. Name all the glassware required. 4. Provide a data table, it should list all the reagent(grams in 10 ml hexane) 0.4 0.004 0.004 and the required quantities needed for the preparation and purification. 1.5 0.4 0.34 (grams in 10 ml Acetone) . Provide a flowchart for the planned synthesis Complete worksheet Attach more sheets of paper as needed PART B: 5 points (replaces pre-lab quiz 10) Using curved arrows to designate the flow of electrons, provide a detailed stepwise mechanism for your planned reaction(s) Ahsan-Riaz-CHE 201 Fall 2017-Lab 10-University at Buffalo 11/10/2017Explanation / Answer
Organic reaction
Procedure for B : Take A ( 5mmol, 0.951g) in a 25 ml round bottom glass flask. Add 10 ml diethyl ether to it. Add aqueous HCl (5mmol,0.18g) to it and stir the reaction at room temperature. Follow the progress of the reaction by running tlc in 20% ethylacetate in hexane solvent. If the reaction is not complete slightly warm up the reaction and let it stir. After the reaction is done, transfer the liquid to a separatory funnel. Add water to ir and shake. Separate the organic layer. Repeat this procedure 2 more times. Add dilute 5% NaHCO3(aq) to it. Shake and separate the organic layer. Wash with lots of water again. The final organic layer is transferred to an 50 ml erlenmeyer flask. Dry the organic layer over anhydrous Na2SO4. Filter the solution and wash residue with diethyl ether. The combined organic layer is transferred to another 50-100 ml round bottom flask and solvent was removed under vaccum on rotary evaporator. The product is obtained. check the purity by taking NMR and melting point.