An essential aspect of drug development is the optimization of the half-life of
ID: 588078 • Letter: A
Question
An essential aspect of drug development is the optimization of the half-life of elimination, which needs to be long enough to allow the drug to find and act on its target organ, but not so long that harmful side effects become important. After intravenous administration of a beta blocker (beta adrenergic blocking agent) the blood plasma of the patient was analyzed for remaining drug concentration at several times after iniection, 2. a. Is the removal of the drug a first- or second-order process? b. Calculate the rate constant and the half-life of elimination c. If the drug loses efficacy below 100 ng/cm3, how long will this injection last? Time (min) Conc. (ng/cm3) 699 622 30 60 120 150 240 360 480 292 152 60 24Explanation / Answer
Order of the given data is Second order
for first oder reaction t 1/2
is indepedent of initial concentration.
for the above problem as initial concentartion increasing half life is decreasing.
{(Ca)^1-n }-{(Ca0)^1-n)}=(n-1)kt
WHERE k IS RATE CONSTANT .