The mutation causing the disease sickle-cell anemia removes one Mst II restricti

Question

The mutation causing the disease sickle-cell anemia removes one MstII restriction site from the beta-globin gene so that a labeled probe, instead of hybridizing to two fragments of 1.1 Kb and 0.2 Kb, hybridizes to one 1.3 Kb fragment. For two parents to have a 25% chance of a child with sickle-cell anemia: a. they must both show only fragments of 1.1 and 0.3 Kb b. they must both show only fragments of 1.3 and 0.2 Kb c. one must show only a 1.1 Kb fragment and the other a 1.1 and 0.2 Kb fragment d. one must show only a 1.3 Kb fragment and the other a 1.1 and 0.2 Kb fragment e. they must both show all three types of fragments The mutation causing the disease sickle-cell anemia removes one MstII restriction site from the beta-globin gene so that a labeled probe, instead of hybridizing to two fragments of 1.1 Kb and 0.2 Kb, hybridizes to one 1.3 Kb fragment. For two parents to have a 25% chance of a child with sickle-cell anemia: a. they must both show only fragments of 1.1 and 0.3 Kb b. they must both show only fragments of 1.3 and 0.2 Kb c. one must show only a 1.1 Kb fragment and the other a 1.1 and 0.2 Kb fragment d. one must show only a 1.3 Kb fragment and the other a 1.1 and 0.2 Kb fragment e. they must both show all three types of fragments

Explanation / Answer

answer b. they must both show only fragments of 1.3 and 0.2 Kb

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