Can someone please help me answer the questions above and explain why did you pi

Question

Can someone please help me answer the questions above and explain why did you pick that answer?

Thanks

His acts as a general acid in serine protease reaction mechanism in what manner? His deprotonates for nucleophillic attack of the peptide backbone. His protonates Ser so that it can act as an electrophile. The protonated imidazole ring contributes a hydrogen to break the peptide bond His deprotonates water for nucleophillic attack of serine The side-chain's oxygen group provides a hydrogen to form the tetrahedral intermediate His acts as a general base in the serine protease mechanism similarly to Asp in the aspartate protease mechanism. How are they similar/different? His and Asp both become nucleophiles to attack the peptide backbone but form different tetrahedral intermediates with the peptide substrate. The side-chain carboxyl group of His deprotonates water, while Asp's imidazole group deprotonates Ser. His deprotonates Ser, whereas Asp deprotonates a water to form nucleophiles involved in general base catalysis His and Asp both create nucleophiles that form tetrahedral intermediates, but His deprotonates water, whereas Asp deprotonates a Ser. None of the above By stabilizing the transition state intermediate, enzymes (mark all that apply) What statement(s) about enzymes are true? (mark all that apply)

Explanation / Answer

1. The answer is The protonated imidazole ring contributes a hydrogen to break the peptide bond. (c).

2. The answer is His deprotonates Ser, whereas Asp deprotonates a water to form nucleophiles involved in general acid-base catalysis. (c)

3. The answer is to reduce the delta G and increase the reaction rate.

4. The answer is bind substrates in their active sites, change the equilibrium of a chemical reaction.

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