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Question #1: In a mitochondrion, the TCA cycle cannot continue on indefinitely w

ID: 62306 • Letter: Q

Question

Question #1: In a mitochondrion, the TCA cycle cannot continue on indefinitely without oxygen because the electron transport chain will be incapable of reducing NADH and FADH2.
a.) True b.) False


Question #2: How much energy (in the form of ATP) would one get from oxidation of 1 pyruvate molecule if the pH gradient was destroyed in the mitochondrion?
a.) 1 ATP
b.) 2 ATP
c.) 10 ATP
d.) 11.5 ATP
e.) 12.5 ATP

Question #3: The Fe-S clusters in the ETC accept electrons but not protons from the preceding step.
a.) True b.) False

Question #4: (1.5 point) High NADH will shut down the TCA cycle at isocitrate dehydrogenase in part because this enzyme requires NAD+ to function.
a.) True b.) False

Explanation / Answer

1. The given statement is (a) true.

2. The correct option is (b) 2 ATP; because oxidation of pyruvate yields 2 ATP.

3. The given statement is (a) true.

4. Isocitrate dehydrogenase (IDH) is an important enzyme in the tricarboxylic acid cycle, which occurs in the mitochondrial matrix.

This enzyme is allosterically regulated negatively by ATP and NADPH, or NADH.

Hence, the given statement is (a) true.