Please give a complete answer for both questios Thanks Claudin-4 normally inhibi
ID: 65333 • Letter: P
Question
Please give a complete answer for both questios Thanks
Claudin-4 normally inhibits movement of Na+ ions across epithelial cells that express it. However, when positively charged amino acids near the tip of the large extracellular loop of claudin-4 are changed to negatively charged amino acids, Na+ can pass through the epithelium. How do you account for this change in permeability to Na+?
In mammalian embryos, the fertilized egg divides 3 times to form eight loosely packed cells, which become tightly adherent in a process called compaction. Antibodies against cell surface proteins found to prevents compaction and remove Ca2+ from the medium. What sort of proteins do the antibody probably recognize and why?
Explanation / Answer
it can happen if Claudin-4 acts as permease and Claudin-4 binds with Na+ when it mutated to get negative charge containing amino acid inplace of positive charge amino acid.
if compactin share some epitope with cell surface protein that is why antibody developed agnaist cell surface protein binds with comcation and prevents compactness and remove Ca++.