Please answer and explain your answer to the following question: You are working
ID: 69492 • Letter: P
Question
Please answer and explain your answer to the following question:
You are working in a biotech company that has discovered a small-molecule drug called H5434. H5434 binds to LDL receptors when they are bound to cholesterol. H5434 binding does not alter the conformation of the LDL receptor's intracellular domain. Interestingly, in vitro experiments demonstrate that addition of H5434 increases the affinity of LDL for cholesterol and prevents cholesterol from dissociating from the LDL receptor even in acidic conditions. Which of the following is a reasonable prediction of what may happen when you add H5434 to cells Cytosolic cholesterol levels will remain unchanged relative to normal cells. .Cytosolic cholesterol levels will decrease relative to normal cells. The LDL receptor will remain on the plasma membrane. The uncoatine of vesicles will not occur.Explanation / Answer
a. is the correct answer.
Explanation: - LDL receptor binds to LDL and thus maintains LDL levels in the blood. The given drug is enhancing the efficiency of LDL receptor for LDL. So, now the receptor will take up more LDL. However, cytosolic cholesterol levels will remain same, because the extra LDL/ bad cholesterol is not dissociating from the receptor. Vesicles will not be formed for the process of endocytosis to occur because of the effect of this drug.