In the Cori cycle, when glucose is degraded by glycolysis to lactate in muscle,

Question

In the Cori cycle, when glucose is degraded by glycolysis to lactate in muscle, the lactate is excreted into the blood and returns to the liver where it is converted back into glucose by gluconeogenesis. For each enzyme below, identify whether it is involved in the glycolysis pathyway, gluconeogenesis pathway, both pathways or neither pathway. 1. phosphohexose(phosphoglucose) isomerase 2. pyruvate carboxylase 3. alcohol dehydrogenase 4. glucose-6-phosphatase

1. phosphohexose(phosphoglucose) isomerase 5. pyruvate kinase O glycolysis O gluconeogenesis O both O neither O glycolysis O gluconeogenesis O both O neither 2. pyruvate carboxylase 6. lactate dehydrogenase O glycolysis O gluconeogenesis O both O neither O glycolysis O gluconeogenesis O both neither 3. alcohol dehydrogenase 7. phosphofructokinase-1 O glycolysis O gluconeogenesis O both O neither O glycolysis O gluconeogenesis O both neither

Explanation / Answer

1 phosphoglucose isomerase used in both glycolysis and gluconeogenesis.

2 pyuvate carboxylase used in only gluconeogenesis

3 alcohol dehydrogenase neither used in glycolysis nor gluconeogenesis

4 glucose 6 phosphatase used in only gluconeogenesis

5 pyruvate kinase used only in glycolysis

6 lactate dehydrogenase used in neither

7phosphofructokinase used in both

8 fumares neither used in glycolysis nor gluconeogenesis

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