I just asked this same question and -- accidentally -- gave a five star to an an
ID: 729722 • Letter: I
Question
I just asked this same question and -- accidentally -- gave a five star to an answer that didn't help at all. WHAT I AM LOOKING FOR IS A DRAWING:I am asked to draw an energy diagram that asks for two things I am unsure of:
a. second intermediate is less stable than the first intermediate. I know what an intermediate is but don't know how stability is seen from an energy diagram. WANT A DRAWING
b. Also, the third step of the reaction is faster than the reverse of the of the first step. How is that seen from an energy diagram. Could someone please illustrate. WANT A DRAWING
Explanation / Answer
A. The nucleophile “attacks” the electrophile from the backside, expelling a leaving group. Recall that SN2 is a concerted reaction, which means all the bond change events takes place at the same time. Now, let’s try making the reaction occur in two steps. What if nucleophilic attack occurred in the first step, creating a CR3 – nucleophile – leaving group intermediate, and then the leaving group was expelled in the second step? B. phosphate cannot diffuse through the membrane, because of its negative charges, the addition of the phosphoryl group begins to destabilize glucose, thus facilitating its further metabolism. The transfer of the phosphoryl group from ATP to the hydroxyl group on carbon 6 of glucose is catalyzed by hexokinase.