Carbon Dioxide and Bicarbonate concentrations in the bloodstream are phsiologica

Question

Carbon Dioxide and Bicarbonate concentrations in the bloodstream are phsiologically controlled to keep pH constant at normal value of 7.40 at 37 degrees C (310 K). Physicians use the following modified form of the Henderson-Hasselbalch Buffer equation to track changes in blood pH.

pH= pKa + log [HCO3^-] / (0.030)(Pco2)

where [HCO3^-1(aq)] is given in millimoles/liter and the arterial blood partial pressure of CO2(g) is given mmHg. The pKa1 of carbonic acid is 6.10. Hyperventilation causes a physiological state in which the concentration of CO2(g) in the bloodstream drops. The drop in the partial pressure of CO2(g) constricts artiries and reduces blood flow to the brain, causing dizziness or even fainting.

Question: If the normal physiological concentration of [HCO3^-1(aq)] is 24 mM, calculate the pH of blood if PCO2(g) drops to 34.0 mmHg.

Question: State a specific conclusion, based on scenario: As the PCO2(g) drops,______H2CO3 and _____ pH

Question: Should the person worry? Calculate Change in pH

Explanation / Answer

Physicians use the following modified form of the Henderson-Hasselbalch equation to track changes in blood pH: pH=Pka+log [HCO3-]/(0.03)(Pco2) where HCO3 is given in millimoles/liter and the arterial blood partial pressure of CO2 is given in mmHg . The Pka of carbonic acid is 6.1. Hyperventilation causes a physiological state in which the concentration of CO2 in the bloodstream drops. The drop in the partial pressure of CO2 constricts arteries and reduces blood flow to the brain, causing dizziness or even fainting.

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