In whole-cell voltage clamp experiments the activity of many channels usually co

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In whole-cell voltage clamp experiments the activity of many channels usually combine and large, smooth shaped currents are observed. Currents carried by different ions can be separated using blocking agents Name a blocker of K^+ channels. And a blocker of Na^+ channels. In the presence of very potent sodium and potassium channel blockers, a Cl^- channel with properties similar to those sketched below was observed in single patches when the membrane potential was stepped from -50 mV to + 50 mV, in symmetric solutions of 100 mM KCl.

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