Answer questions 63-75 directly on these pages. now into the which this have on
ID: 93277 • Letter: A
Question
Answer questions 63-75 directly on these pages. now into the which this have on neuron A its 60 mv. effect might membrane potential of What A will de membrane less egati make the neuron imore likely to an more D. I will make the neuron less likely to fire an action potential. will trigger voltage-gated Na ion channels to open F, A, B & E are correct 64) Number the followi events describing the mechanism of gnal transduction for the event that occurs first, etc. dwI the coroner temporal order beteroerimerie G-protein interacts with the receptor adenylate cyclase or L a subunit of G-protein with bound GTP interacts with effector enzyme Cie. phospholipase CB) activation of kinase (protein kinase A or by second messengers ligand signal or bormone) binds to receptor, initiating a conformational change in the receptor. G-protein exchanges GDP for GTP, production of second messenger (e. CAMP or DAG P3). phosphorylation of available substrates, Use the following set of responses to answer questions 65-73. (One answer per question; each answer is used only once.) CAMP B. DAG (diacylglycero) C. receptors with intrinsic kinase activity D. NO F. G protein-linked receptors G. changes in gene expression H. ras EG-proteins 65. gaseous signalling molecule that activates guanylyl cyclase 66, integral membrane proteins that contain seven transmembrane domains. 67. messenger produced by phospholipase C that causes the release ofca upon binding to recept the 68. a monomeric G-protein; mutations in the gene encoding this protein is observed in many human cance 69. a-subunit binds GTPAGDP 70. nonpolar second messenger that activates protein kinase C. 71. integral membrane proteins with a single transmembrane domain and an extracellular igand Chormor 72. a possible cellular response to an external signal. 73. binds to the regulatory subunit of protein kinase A.Explanation / Answer
Question 63 not readable
Ans-64
Ligand binds to receptor, initiating conformational change in the receptor_ heterodimeric protein interact with the receptor_G-protein exchanges GDP for GTP (activate alpha subunit)_bound alpha subunit with GTP interact with the effective enzyme (i. Adenyl cyclases or PLC)_activated enzyme produces second messenger (i.e cAMP, DAG+IP3)_secondary messenger activates kinase (PKA or PKC)_phosphorylation of available substrate or PKC phosphorylates CREP transcription factor.
Ans-65 (D)
NO- binds to heme molecule present in gaunyl cyclise and activate it.
Ans-66 (F)
G-protein linked receptor also known heptahelical or serpentine receptor.
Ans-67 (E) IP3
Inositol 1,4,5-triphosphate (IP3) which binds to ligand-gated Ca2+ channels in ER and release Ca2+
Ans-68 (H) ras
Ras is a G protein, or a guanosine-nucleotide-binding protein which is related in structure to the G subunit of heterotrimeric G proteins. Mutations in the Ras family of proto-oncogenes are very common, being found in 20% to 30% of all human tumors.
Ans-69 (I) G-protein
G-protein alpha-subunit binds GTP/GDP
Ans-70 (A) DAG
DAG is the non polar secondary messenger which activates PKC.
Ans-71 (C) receptor with intrinsic kinase activity
e.g. receptor tyrosine kinase (RTKs) comprises extracellular domain containing a single ligand binding site , a single hydrophobic transmembrane alpha helix, and a cytosolic domain that includes a region with protein tyrosine kinase activity.
Ans-72 (G)-changes in gene response
Ans-73 (A)cAMP
4 cAMP molecules are required to activate PKA (R2C2; 4 subunit)