Acetyl.CoA (= Acetyl Coen/ym A. shown below) is a crucial reagent in the biosynt

Question

Acetyl.CoA (= Acetyl Coen/ym A. shown below) is a crucial reagent in the biosynthesis of fatly acids, cholesterol. and other his molecules Acetyl-CoA is a so-called thioester of Coenzyme A. Beside Acetyl-Co A. many other CoA esters are fmind in various biosynthesis. Shown below are three steps in the biosynthesis of cholesterol. Please stale which organic reagent(s) (no en/ymcs please) could be used to make each of the three steps possible. What is the organic mechanism called for each of the three transformations?

Explanation / Answer

Step 1 -- > 2 molecules of same compound undergoes aldol condensation in presence of acid.(H2SO4)

Step 2 ---> hydrolysis of CoA (which is a good leaving group) is done in presence of base.(NaOH)

Step 3 ----->  hydrolysis of CoA (which is a good leaving group) is done in presence of acid.

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