Acetyl-CoA, necessary for synthesis of fatty acids, is produced in the matrix of
ID: 97147 • Letter: A
Question
Acetyl-CoA, necessary for synthesis of fatty acids, is produced in the matrix of the mitochondria. Which of the following genetic defects would directly inhibit fatty acid synthesis? A mutation in the gene for carnitine acyltransferase I A mutation in the gene for succinate dehydrogenase A mutation in the gene for citrate transporter A mutation in the gene for hexokinase A mutation in the gene for acyl-CoA dehydrogenase (first enzyme in beta-oxidation) After you have eaten a meal (well-fed state, high blood glucose) the hormone ___ (1) ___ is released, which stimulates dephosphorylation of target enzymes. In the case of cholesterol biosynthesis, the rate-limiting enzyme ___ (2) ___ is dephosphorylated, which ___ (3) ___ cholesterol biosynthesis. (1) insulin: (2) HMG-CoA reductase: (3) activates (1) glucagon: (2) HMG-CoA reductase: (3) inactivates (1) insulin: (2) acetyl-CoA carboxylase, (3) activates (1) glucagon: (2) fatty acid synthase: (3) inactivatesExplanation / Answer
1. A mutation in the gene for acyl-CoA dehydrogenase (first enzyme in beta-oxidation).
2. 1. Glucagon.
2. HMG-CoA reductase
3. inactivities.