What are the conditions that lead to a \"beer gut\" due to excess consumption of
ID: 96402 • Letter: W
Question
What are the conditions that lead to a "beer gut" due to excess consumption of alcohol?
A) NADH produced from the metabolism of ethanol stimulates the citric acid cycle for glucose-derived acetyl CoA.
B) Excess ethanol metabolism leads to an accumulation of NADH that inhibits fatty acid metabolism.
C) NADH stimulates citric acid cycle enzymes that stimulates glucose-derived acetyl CoA metabolism.
D) NADH inhibits ketone body formation, stimulating glucose rather than fatty acid metabolism.
E) The processing of acetate in the liver becomes inefficient leading to pH imbalance in liver cells, reducing enzyme efficiency in general.
Explanation / Answer
Answer: B) Excess ethanol metabolism leads to an accumulation of NADH that inhibits fatty acid metabolism. (As explained below).
Alcohol is broken down into acetaldehyde and nicotinamide adenine dinucleotide (NADH) by the enzyme alcohol dehydrogenase (ADH). Excessive levels of alcohol produce excessive NADH. This excess NADH acts as a reducing agent for glycerol and Fatty acid synthesis. Therefore increased lipids cause weight gain and beer gut. conditions.