Remember! Please submit answers using full sentences and correct punctuation of
ID: 97413 • Letter: R
Question
Remember! Please submit answers using full sentences and correct punctuation of names.
1. The viral genome is +RNA in picornavirus. Identify three species or more specific serotypes of picornavirus that affect humans. Then list what type of disease they cause: (2 points)
a.
b.
c.
Receptor binding Pro-apoptotic Anti-apoptotic effects effects Entry Shut off host cell (cap- dependent) translation Shut off host cell transcription Polyprotein st Interactions between the virus and the cell cycle Uncoating Viral replication complex Negative strand synthesis 5 dsRNA (latency?) IRES-driven translation strand (genome) 5 3 3' 3' 3 5 Packaging Cell lysis Viral egressExplanation / Answer
Answer=
three species or more specific serotypes of picornavirus that affect humans are as following
1] Enteroviruses= human enterovirus A serotypes are A2 (CV-A2) ,CV-A3.CV-A4 ,CV-A5
2] human coxsackieviruses A1-22,24
3] Rhinovirus A -A1,A2 ,A7,A8,A9,A10,A11
picornavirus causes the following type of diseases
1] poliomyletis= poliovirus has tropism for epithelial cells of the alimentary tract & cells of the central nervous system .infection is asympiomatic or causes a mild ,undifferentiated febrile illness.
Spinal & bulbar poliomyletis often occure
2] Respiratory illness- enterovirus types 68 & 69 cause respiratory illness.
type 70 causes acute hemorrhagic conjunctivities & occasionaly polio like radiculomyelitis
3] common cold - Rhinoviruses cause mainly respiratory infections including common cold.
4] Hepatitis A - Hepatitis A virus causes gastroenteritisinfections & hepatitis A.