If you were to replace 2-acetylpyridine with acetophenone in an adol reaction of
ID: 975664 • Letter: I
Question
If you were to replace 2-acetylpyridine with acetophenone in an adol reaction of 2-acetylpyridine and 4-nitrobenzaldehyde would the reaction speed increase, decrease, or stay the same? Why? How would you monitor this reaction to determine when it has reached completion? If you were to replace 2-acetylpyridine with acetophenone in an adol reaction of 2-acetylpyridine and 4-nitrobenzaldehyde would the reaction speed increase, decrease, or stay the same? Why? How would you monitor this reaction to determine when it has reached completion?Explanation / Answer
The rate of aldol condensatio will increase .
The reason is acetophenone is more acidic than 2-acetylpyridine so the acidic hydrogen is removed more rapidly.