Consider the endocrine feedback systems shown in Figure 1. Please indicate the s
ID: 101728 • Letter: C
Question
Consider the endocrine feedback systems shown in Figure 1. Please indicate the short-term (minutes to hours) and long-term (days) effects on the plasma level of Hormone and on the output of the Target Tissue of the following changes listed below. Explain your reasoning
b. Increase in the Concentration of Carrier Protein
c. Liver or Kidney disorder
e. Inactive receptor at the Endocrine Gland
f. Insensitivity of the Endocrine Gland to X
CarrierProtein Stimulus Endocrine Gland Target Tissue Liver Metabolism/ Kidney Excretion (-) indicates a negative effect/feedback; (+) indicates a stimulating effectExplanation / Answer
Carrier proteins are necessary for transportation of hormone from gland to distance sites.
So increase in carrier protien concentration causes short-term rise in plasma concentration of hormone and increase in effects but due to negative feedback and liver metabolism on long term the hormone plasma concentration decreases thereof effect on target organs and its output.
In liver or kidney disorder no hormone gets excreted so on short-term there normal plasma hormone concentration and Target organ responce.but on long term there is accumulation of hormone and its plasma plasma conc increases.so feedback mechanism starts and lowers the conc and hence lower its effect on target tissues and the output.
If receptors on the endocrine gland is inactive feedback mechanism fails.and the gland keeps producing the hormones.for short term there is increase in conc of hormone and its effect on target organ increase but for long-term due to lack of feedback concentration remain increased there is hyperactivity of the target organ.
In case of insensitivity of the endocrine gland for X there is no production of hormone both for short-term and long-term.
So there occurs no increase in conc of hormone and no increase in effects on target organ and its output in both long-term And short-term.