IIRey (2) -Comp...Q Layout References Mailings Review View For questions 40-42,
ID: 145148 • Letter: I
Question
IIRey (2) -Comp...Q Layout References Mailings Review View For questions 40-42, use this protein alignment table made for HIV GAG protein. Aligned Sequences HIV-2 RLRPEGKKK RKHIVWAANELDRFGLAESLLES SIVM4239 MOV ,1-1.SVLSGKI L KRLRP GKKK KhwanNEI.DRrot.AEStin SIVAGM3 MGA-SAL NRROL HIV-1 SIVCpz SIVmon 41. What residue position would be defined as a conservative substitution site? a. Position 31 b. Position 17 c. Position 14 d. Postion 5 42. What residue position would be defined as a non-conservative substitution site? a. Position 31 b. Position 17 c. Position 14 d. Postion 5 43. What residue position(s) would you suggest to be important for biological function? a. Position 31 b. Positions 21-24 c. Position 17 d. Position 14Explanation / Answer
41]A conservative replacement (also called a conservative mutation or a conservative substitution) is an amino acid replacement that changes a given amino acid to a different amino acid with similar biochemical properties (e.g. charge, hydrophobicity and size).
substitution of one amino acid residue for another has a far greater chance of being accepted if the two residues are similar in properties.
Position 17
42]nonconservative substitution one amino acid is substituted by another which has markedly different polarity.
Position 31
43]Position 21-24 Repaeted amongst all the species.High probability that its a biologically functional domain.