Part A Given that these are debilitatng conditions, why has no cure been develop

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Part A Given that these are debilitatng conditions, why has no cure been developed? The delective mitochondria would need to be corrected for a cure to be achieved, and that appears to be technologically impossible at this time The defechve emitochondria would need to be corected for a cure to be achieved, and that may cause damage to the whole organism. The defective mitochondria would need to be corrected for a cure to be achieved, and that appears to be very expensive The defective mitochondria wouold need to be idendtied for a cure to be achieved, and that appears to be technologicaly impossible at this time Submit Request Answer Part B Can you sugpust a general approach that might be used to treat, or perhaps even cure, these disorders? e Suppress the replication of mutant mitachondria and favor the replication of normal mochondria Favor the reptication of both mutant and normal mitochondria suppress the repication of both mutant ard normal mnochondna Suppr oss the replicaton of normal mnochondria and ravor the replication of mutant mitochondria Submit Request Answer

Explanation / Answer

NOTE: I have answered all three parts, but in future please upload images of higher clarity so it is easy to read. also please upload screenshots, rather than taking an image of your laptop screen with another device or some such.

PART A: Ans Option 4- the defective mitochondria would need to be identified for a cure to be achieved, which is technologically not possible at this time.

We are currently not in a position to differentiate defective mitochondrial sequences during organelle formation stages as there are no phynotypic markers for the same.

PARTB: Ans Option 1: Suppress the replication of mutant mitochondria and favour the replication of normal mitochondria.

For obvious reasons, suppressing the replication of mutant mitochondria would be advantageous in removing the promulation of erroneous sequences that cause such debilitating diseases.

Part C: Ans Option 1 It maybe possible to alter the heteroplasmic ratio by microinjection of mitochondria.

If wild type (non mutant) mitochondria can be microinjected into this bottleneck phase, it can be used to predominantly spread the replicating cells with normal mitochondria and potentially repress such diseases.

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