Answer the following question in paragraph form. Imagine one of Dr. Tim Mousseau
ID: 170828 • Letter: A
Question
Answer the following question in paragraph form. Imagine one of Dr. Tim Mousseau’s barn swallows in the Chernobyl exclusion zone. A) What kind of DNA damage would it likely sustain from ionizing radiation (X-rays/gamma rays) in the exclusion zone? B) How would cell cycle checkpoints help protect it from harmful mutations? Discuss the DNA damage checkpoint in detail, mentioning all of the molecules that are involved and their roles, such as p53, cyclin, protein kinases, etc. C) Under what circumstances would mutations resulting from DNA damage be passed to the next generation of barn swallows? D) What kinds of inherited mutations would be likely to remain in the population of barn swallows 100 years from now?
Explanation / Answer
When the blood samples were collected from the Barn swallows it was found that the the levels of damage of the DNA are more when compared to the Barn swallows living in the low ready radiation sites. The results indicate that chronic exposure to Radioactive contaminants even after 20 years of the accident at the nuclear power plant continue to induce DNA damage in the cells of living animalse.
P53 is activated in response to DNA damage associated with Rapid increase in its level and its ability to bind DNA this leads to activation of number of genes to Trigger cell cycle arrest DNA repair apoptosis. It arrest the cell cycle in the G1 phase.
Cycling are having no enzymatic activity but they have binding sites for some substrates and the target SEBI case two specific subcellular locations when Bond with kinases activate other proteins through phosphorylation which are responsible for specifications during cell divisionm. The cyclin-dependent kinase complex is formed by the association of inactive subunit of protein kinase cyclin dependent kinase with regulatory subunit cyclin. Deregulation of this family of proteins causes several diseases including cancer drug targeted inhibition of specific members Prove the results.
When the mutations occur in the sex chromosomes the rate of sperm production will be affected resulting in law mutations in the next generation
Radiation induced mutations can purchase for a work persist for many generations until they are selected out of the gene pool by evolutionary processes radiation increases genomic instability the future generations who were never exposed to radiation significantly become more sensitive to renew radiation based upon the extent of damage to the DNA inherited bioaccumulation is another factor