Please answer the following genetics question I\'m not sure if my calculations a

Question

Please answer the following genetics question I'm not sure if my calculations are right or if I'm even doing the right thing. Help!):

1.) With the two sequences “ATCGGCTAATCTC” and “ATCCTAATCTC”, and the alignment rule guide below, calculate the alignment score for each of the alignments proposed here. Please note that the penalty for gap opening is -8 and for gap extension is -3.

t score calculates out to be: ATGC A5-4-4-4 T-45-4-4 G-4-45-4 C-4-4-45 Score from substitution matrix Alignment 1: ATCGGCTAATCTC ATCCTAATCTC Alignment 2 ATCGGCTAATCTC ATC CTAATCTC C4445 G4454 T4544 CIC A5444 11 CIC 5 o5b A-C A-A s+ 05 e5t AIT AIA 405 lo 4 e5 a+ C-A CIC GIT a5 c+ t4 GIC 42 t8 CIC CIC 5 er 5 A-A T5A5

Explanation / Answer

For calculating alignment score, we have to consider gap opening (-8) and gap extension (-3) also.

The allignment score are as follows:

Alignment 1: 5+5+5-4-4-4-4-4-4+5+5-8-3 = -10

Alignment 2: 5+5+5-8-3+5+5+5+5+5+5+5+5 = 44

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