Can you please give reasoning why each of the statements are true or false? Than
ID: 206478 • Letter: C
Question
Can you please give reasoning why each of the statements are true or false? Thanks in advance!
04. I have mutant cells that make no PFK2 enzyme. I measure rates of oxygen consumption in these mutant cells and compare them to wild type cells. What is the MOST LIKELY outcome of this experiment? F F F F ? ? ? ? T A) Mutant cells will have the same 02 consumption as wild type; PFK2 does not affect the ETC B) Mutant cells will have increased 02 consumption; they will need to increase ETC C) Mutant cells will have decreased 02 consumption; decreased glycolysis leads to D) Mutant cells will have increased 02 consumption: decreased PFK2 will increase to compensate for lack of PFK2 T decreased TCA and ETC glycolysis, which will increase ETCExplanation / Answer
The correct option is C. Mutant cells will have decreased O2 consumption; decreased glycolysis leads to decreased TCA and ETC .
A) Mutant cells will have the same O2 consumption as wild type; PFK2 does not affect the ETC - False.
B) Mutant cells will have increased O2 consumption; they will need to increase ETC to compensate for lack of PFK2 - False.
D) Mutant cells will have increased O2 consumption; decreased PFK2 will increase glycolysis, which will increase E - False.
An enzyme PFK2, which is responsible for regulate of the rates of glycolysis and gluconeogenesis process in the human body. Concentration of F-2,6-BP is regulated by the action of PFK2. In the absence of F-2,6-BP, PFK is not activated and stops the process of glycolysis. TCA cycle and ETC will stop in the absence of process of glycolysis.PFK2 increases F-2,6-BP, which activates glycolysis by allosteric activation of PFK1 and increase the amount and level of glucose.