Please answer the whole page. Pedigree 2 -Below is a pedigree showing the patter
ID: 209954 • Letter: P
Question
Please answer the whole page.
Pedigree 2 -Below is a pedigree showing the pattern of inheritance of a rare genetic condition in a particular family 2 2 3 4 2 3 4 56 78 9 10 11 12 X-linkd nuasi 1. What is the most likely mode of inheritance for the trait? 2. 3. Provide as much as possible the genotype of each of the following: a. b. 1-1 C. 1-2 f. IV-4 g. V-5 4. What is the probability that individual IV-3 is heterozygous? 5. If V-2 and V-4 were to have a son together, what would be the probability of it being affected?Explanation / Answer
As the disease is X link recessive, in female if both recessive xx is present than it affect the female but male have only one X chromosome hence in any case male is affected.
2..
I-1 is heterozygous normal female (Xx)
I-2 is a normal male (XY)
II-2 heterozygous normal female (Xx)
II-4 affected male (XY)
IV-4 heterozygous normal female (Xx)
V-5 homozygous affected female (xx)
3..in the present case IV-3 is absolutely normal XX however her sister is heterozygous(Xx). She is normal because her father is normal and mother is heterozygous (Xx) carrier.
4.. if V2 and V4 have son, 50% of son are affected (xY) and 50% are normal (XY) because their father is normal and mother is carrier.