Individual Phenotype Genotype at the enhancer of the Lactase gene (position 1392
ID: 221386 • Letter: I
Question
Individual
Phenotype
Genotype at the enhancer of the Lactase gene (position 13923 – 13902 upstream of the gene)
Bjorn
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGTCCCTGG
Chris
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGTCCCTGG
Esiankiki
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Xiao-Ma
Lactose intolerant
Copy 1: TAAGATAATGTAGCCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Linda
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Sanjeet
Lactose intolerant
Copy 1: TAAGATAATGTAGCCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Looking at the data above, can you correlate a genetic di erence between the individuals with tolerance or intolerance to lactose?
Does your findings support or disprove the hypothesis that the SNP at 13910bp from LCT is correlated with lactase persistence?
Individual
Phenotype
Genotype at the enhancer of the Lactase gene (position 13923 – 13902 upstream of the gene)
Bjorn
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGTCCCTGG
Chris
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGTCCCTGG
Esiankiki
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Xiao-Ma
Lactose intolerant
Copy 1: TAAGATAATGTAGCCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Linda
Lactose tolerant
Copy 1: TAAGATAATGTAGTCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Sanjeet
Lactose intolerant
Copy 1: TAAGATAATGTAGCCCCTGG
Copy 2: TAAGATAATGTAGCCCCTGG
Explanation / Answer
Answer:
1. Yes.
Copy 1: TAAGATAATGTAGTCCCTGG (from Bjorn)
All lactose tolerant individuals have at least one T allele in the underlined position.
2. The findings appear to support this.
The data indicates that the presence of one single lactase-persistence allele in the heterozygous state has a dominant effect, rendering the person a lactose digester, whereas the genotype LCT- 13910CC, when the lactase-persistence allele LCT-13910T is absent, is consistent with lactose maldigestion.