Please explain question 3 apter 21: Epigenetics Folate is a source of S-adenosyl

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Please explain question 3

apter 21: Epigenetics Folate is a source of S-adenosyl Low levels of maternal folate levels during growth of the placenta and uterus, and intrauterine growth retardation. methionine (SAM), which is used to supply DNA methyltransferases with methyl groups. pregnancy are associated with an increased risk of preterm delivery, poor 1. Where do pregnant women normally get folate? 2. identify the specific changes that are caused by DNA methyltransferases 3. Explai n the series of events that would occur with low levels of folate that would influence fetal growth.

Explanation / Answer

Ans.1). Pregnant womenet folate form a variety of food items, such as vegetables (broccoli, asparagus, and spinach), legumes (lentils, chickpeas, and dried beans), and fruits (oranges, strawberries, and bananas). Folate supplements can also be taken by pregnant women to fullfil the daily dose requirment.

Ans.2). DNA methyl transferase is an important enzyme that causes methylation of cytosisne and converts into 5-methycytosine. It regulates cell differentiation and gene expression. Changes caused by DNA methyl transferases include long term silencing of genes, inactivation of X-chromosome, silencing of transposons, cancer development, and supression of viral genes expression.

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