Map do Sapling Learning The table below shows the partial sequences of a wild ty
ID: 254425 • Letter: M
Question
Map do Sapling Learning The table below shows the partial sequences of a wild type polypeptide and three mutant polypeptides, as well as the type of single nucleotide mutation that produced each mutant polypeptide. Peptide Wild type Met-Leu- Arg-lle- Mutant 1 Met-Leu- Arg-Met- Mutant 2 Met Leu-[STOPI Mutant 3Met-Phe Arg-lle- Type of mutation transition transversion peptide by identifying the codons that correspond to each amino acid. The first codon has been filled in for you. The codon table may be found here. Met Leu Arg le AUG AGA CGG AUU CUA CGA AUA CUU UUAExplanation / Answer
Transitions are interchanging of purines or pyramidines, therefore they involve bases of similar shapes.
Transversions are interchanging of purine for pyramidine bases and vice versa.
Accordingly, in Mutant 1 transition leads Ileu to Met i.e., AUA to AUG ( A to G - Transition)
in Mutant 2 transversion leads Arg to STOP codon i.e, AGA to UGA (A to U - Transversion)
in Mutant 3 transition lead Leu to Phe i.e, CUU to UUU ( C to U - Transition)
So the sequence of the given polypeptide is
AUG CUU AGA AUA