Can someone explain to me what this is? I do not undertsand Donar Sirain1onorSra
ID: 255524 • Letter: C
Question
Can someone explain to me what this is? I do not undertsand
Donar Sirain1onorSrainBnor Stran B) Dorer Srain A B Donor (Strain B) Donor (Strain Ax B) MHCb Donor (Strain B) ???? MHCab Skin graft Recipient Strain A, HCa) Recipient (Strain A, MHCa) Recipient (Strain Ax B MHCeb) Recipient (Strain A ????) Graft No Yes No Yes reiection Syneneic Fully allogeneic Graft from inbred Graft from Fi hybrid graft is ejectedrejected by F hybridparental strain graft is not parental strain is notisrejected by inbred rejectedExplanation / Answer
MHC = Major Histocompatability Complex. Animals have MHC on the cells of all organs. The MHC is like blood group factor. For a person to recive graft from a donor, both must have same MHC. Otherwise, the graft would be rejected.
In A, both donor and recepient have same MHCa . Hence, the graft is accepted.
In B, donor has MHCb and recepient has MHCa . Hence graft is rejected.
In C, Donor has MHCb and recepient has both MHCa/b . Hence the graft is not rejected. THe recepient has both MHCa and MHCb . Hence it does not elicit immune response to MHCb coming from the donor.
In D, the recepient has only MHCa which means it considers MHCa/b graft as foreign antigen since it contains b . So, the graft is rejected.