QUESTION 2 atch a principle or feature of the design/conduct or analysis of expe

Question

QUESTION 2 atch a principle or feature of the design/conduct or analysis of experimental studies (trials) with their intended aims or rposes Randomization, which refers to the assignment of a- Aims to preserve the benefits of randomization study subjects or any other type of units to be allocated to the study intervention arms at random, .Gain in study efficiency (producing two studies from one) using either a table of random digits or a computer c Provides justification, ethical and scientific, of the trial generated list of random numbers d Making the groups as comparable as possible in every V Intention to treat: Preserving the groups being compared as similar to those produced by randomization single respect, except in assignment to the study interventions e Preventing information bias Factorial design, that is, the arrangements of study groups by combining different study arms (e.g. 2 interventions A and B, would produced four combinations: A+B, A+placebo, B+placebo and placebo only) Blinding or masking, that is the concealment of the study intervention to either the study participants, the interviewers or persons conducting the assessments, or the investigators/statistical analysts -[7] Equipoise, theexistence of a real uncertainty about the effects of the intervention

Explanation / Answer

1. Randomization , which refers to the assignment of study subjects or any other types of units to be allocated to the study intervention arms at random using either a table of random digits, or a computer generated list of random numbers. It prevents selection bias and insures aginst the accidental bias. option(e)

2. Intention to treat: preserving the groups being compared as similar to those produced by randomization.(b)gain in study efficiency.

3.Factorial design, that is, the arrangements of study groups by combining different study arms(example 2 interventions A and B, would produce four combinations: A+B,A+placebo, B+ placebo and placebo only.) Factorial design allows researchers to look how different factors affect adependent variable.option(d)

4. Blinding or masking, that is the concealment of the study intervention to either the study participants, the interviewers or persons conducting the assesments, or the investigators/ statistical analysis.(a) Aims to preserve the benefits of randomization.

5.Equipoise, The existence of a real uncertainity about the effects of the intervention.This involves assigning patients to different treatment arms.(c) provides justification, ethical and scientific , of the trial

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