I need to write a paper on type I Diabetes and i have answered questions 1,3, an
ID: 3513999 • Letter: I
Question
I need to write a paper on type I Diabetes and i have answered questions 1,3, and 4 on my own but i need help with question 2.
For each disease, you will write a short paper (no more than 1000 words total) addressing each of the following:
1) What is the genetic basis of the disease?
***2) What is the molecular basis of the disease? (what is abnormal at the cellular, biochemical, or molecular level?)
3) What are the physiologic implications of the disease? (what is abnormal about the physiology of people with this disease?)
4) What are the treatment options?
Explanation / Answer
2.Type 1 diabetes wecan say its a T cell mediated autoimmune disease, which is characterised by the selective destruction of pancreatic ? cells. The environmental agents implicated include viruses and dietary factors, although none has yet been shown to be directly responsible for triggering ? cell autoimmunity.This destructive process causes severe insulin depletion, which then results in hyperglycaemia, because of hepatic overproduction of glucose by glycogenolysis and gluconeogenesis and reduced cellular uptake of glucose from the circulation. In the absence of insulin, there is also an increase in fat breakdown and fatty acid oxidation, resulting in the excessive production of ketones. If this left untreated, these metabolic disturbances can lead progressively to central nervous system depression, coma, and death. Thus, the disease requires life long treatment with exogenous insulin to improvelife expectancy.