QUESTION 2 Clomifene is a drug that is commonly used to increase fertility in wo
ID: 3514014 • Letter: Q
Question
QUESTION 2 Clomifene is a drug that is commonly used to increase fertility in women who are infertile because they cannot ovulate or they ovulate infrequently. The primary effect of clomifene is to inhibit estrogen receptors in the hypothalamus. The drug is usually administered from day 3 to day 8 of the ovarian cycle. With these facts in mind, combined with what you know about the endocrine regulation of the ovarian cycle, which one of the following statements is most likely false? a. In women with normal ertility, untreated with clomifene, rising levels of FSH early in the ovarian cycle cause the growth of a few follicles. D.With clomifene present from day 3 to day 8, levels of GnRH secretion would be lower than without clomifene. c. With clomifene present from day 3 to day 8, levels of FSH secretion would be higher than without clomifene. d. Clomifene treatment would stimulate the growth of more follicles, increasing the likelihood of successful ovulation.Explanation / Answer
B. With clomiphene present between day 3 and day 8, levels of GnRH secretion would be lower than without clomiphene .
Clomiphene does not inhibit secretion of GnRH and if level of GnRH would be lower, FSH secretion would be reduced and follicle maturation would be inhibited.