Plasma proteins do not ordinarily enter the glomerular filtrate. In the presence
ID: 40210 • Letter: P
Question
Plasma proteins do not ordinarily enter the glomerular filtrate. In the presence of pathology that makes the glomerulus leaky, plasma proteins cna be filtered with serious consequences for renal functioin, and also for other function of the body.
Consider an individual who develops pathology that results in a leaky glomerulus.
1. Predict the changes (Increase, Decrease, No Change) that will be present in the following paramaters as a consequence of this pathology.
A. Plasma Protein Concentration
B. Plasma Colloid Osmotic Pressure
C. Plasma Volume
D. Interstitial Fluid Volume
Explanation / Answer
a. In a leaky glomerulus condition, the plasma protein concentration is decreased, though heavy molecular weight substances like proteins are not filtered out but due to leaky condition of glomerulus the proteins are lost through filtrate and hence the plasma protein concetration decreases.
b. Since, the protein concentration is decreased the plasma colloidal osmotic pressure is also decreased.
c. The plasma protein concentration is decreased and plasm become thin or light and hence its volume is increased.
d. The decreased protein concentration in plasma causes the accumulation of interstitial fluid in the cells and hence the volume of interstitial fluid is increased.