Plasma proteins do not ordinarily enter the glomerular filtrate. In the presence
ID: 40211 • Letter: P
Question
Plasma proteins do not ordinarily enter the glomerular filtrate. In the presence of pathology that makes the glomerulus leaky, plasma proteins can be filtered with serious consequences for renal function, and also for other functions of the body.
1. As a result of fluid shifts between the vascular and the intersitial compartments additional changes in function affect cardiovascular and renal function. Predict the changes (Increase, Decrease, No Change) that will occure in the following parameters?
A. Blood Pressure
B. GFR
C. Plasma renin concentration
D. Plasma aldosterone concentration
E Vasopressin secretion
Explanation / Answer
A. Due to leaky glomerulus, the plasma protein concentration is decreased and hence the blood pressure is increased.
B. When the proteins are filtered through leaky glomerulus, its efficience is decreased and hence the GFR (glomerular filtration rate) is also decreased.
C. Plasma renin concentration is increased due to decreased GFR.
D. The leaky glomerulus causes the plasma aldosterone concentration to increase.
E. Vasopressin secretion is also increased and dilates the blood vessels due to decreased GFR and increased plasma and interstitial fluid volume.