Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphory

Question

Hexokinase catalyzes the first step of glycolysis, in which glucose is phosphorylated to form glucose-6-phosphate Which of the following statements are accurate? Choose all that apply Most kinases require the presence of a monovalent metal ion cofactor to prevent ATP hydrolysis. Hexokinase transfers the terminal phosphate of ATP to carbon 3 of glucose. Hexokinase consists of two domains, or lobes, that come together when glucose and the MgATP2 complex are bound. Hexokinase is found in the cytosol. Hexokinase is a type of transferase that catalyzes the transfer of a phosphoryl group from ATP toa hexose. Because hexokinase brings the OH of glucose close to ATP, the hydroxyl group of water can enter the active site and hydrolyze ATP to ADP and Pi.

Explanation / Answer

1. Most kinases require the presence of monovalent metal ion cofactor to prevent ATP hydrolysis. ---> TRUE

2. Hexokinase transfers the terminal phosphate of ATP to carbon 3 glucose. ------------------------------> FALSE (Hexokinase transfers the terminal phosphate of ATP to water).

3. Hexokinase consists of two domains, or lobes, that come together when glucose and the Mg ATP2- complex are bound.   -------------> TRUE

4. Hexokinase is found in the cytosol. --------. TRUE

5. Hexokinase is a type of transferase that catalyzes the transfer of a phosphoryl group from ATP to a hexose. -----> TRUE

6. Because hexokinase brings the OH of glucose close to ATP, the hydroxyl group of water can enter the active site and hydrolyze ATP to ADP and Pi. ----------------> TRUE

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