Imagine one small human population, 100 people from a small town In Eastern Euro
ID: 67193 • Letter: I
Question
Imagine one small human population, 100 people from a small town In Eastern Europe. As scientists, we are interested in looking at one genetic locus with two possible alleles. Genetic testing, which searches for a particular target allele, shows that 20 of the people in this town are heterozygous for the CCRS-Delta 32 mutation that confers resistance to HIV. An additional 10 people are homozygous for the CCR5-Delta 32 mutation. Calculate the genotype frequencies in this population: P = What is the genotype frequency (P) of CCR5 / CCR5? H = What is the genotype frequency (H) of CCRS / CCR5-Delta 32? Q = What is the genotype frequency (Q) of CCR5-Delta 32 / CCR5-Delta 32? Do your genotype frequencies add to 1.0? (this is an important check: if there are only three possible genotypes, all of them should be accounted for in your frequency data) Calculate the allele frequencies in this population: If there are 100 people, each of which has two alleles at this locus, how many alleles (total) are there in this diploid population's gene pool? P = What is the allele frequency (p) of the wild-type CCR5 allele? q = What is the allele frequency (q) of the CCRS / CCR5-Delta 32 allele? Do your allele frequencies add to 1.0? (this is an important check: if there are only two possible alleles, all of them should be accounted for in your frequency data)Explanation / Answer
Actually Genotype frequency in a population is the number of individuals with a given genotype divided by the total number of individuals in the population. This can be calculated by Hardy-Weinberg equation.
By putting these values we get Genotype frequency (P) = 0.6
Genotype frequency (Q) = 0.4 and Genotype frequency (H) = 0.2