Patients who have very serious kidney or liver diseases might need an organ tran
ID: 74929 • Letter: P
Question
Patients who have very serious kidney or liver diseases might need an organ transplantation: their organ needs to be replaced with that of a MHC-compatible donor. During the transplantation operation, patients receive drugs that temporarily suppress their immune system. A hospital where patients undergo transplantation operations learns about your influenza vaccine and purchases it from you because they are afraid that patients might get influenza virus infection. However, although they use your vaccine, the patients in the hospital still develop influenza infection very often. When you sequence the influenza virus genome obtained from patients in this hospital (in 2012) you find that this is strain #3. How can you explain this?Explanation / Answer
There may be changed of antigenic shift which changes the surface antigen occurs due to genetic recombination., which result in periodically change in hemagglutnin and neuraminidase..sequential evolution within immune or partially immune population are responsible for antigenic drift that lead to inactivation of given vaccine.