Place the steps involved in processing of extracellular, vesicular antigens in t
ID: 92159 • Letter: P
Question
Place the steps involved in processing of extracellular, vesicular antigens in the correct chronological order. _____ Ii guides MHC class II molecule out of endoplasmic reticulum and into a vesicle. _____ CLIP is released by HLA-DM binding. _____ MHC class II molecules intersect with the phagolysosomes, where peptides are degraded by enzymes into smaller peptide fragments. _____ MHC class II molecules progress towards cell membrane in membrane-bound vesicles. _____ Invariant chain (Ii) binds to the MHC class II antigen-binding site to prevent premature binding. _____ Proteolysis cleaves I i into smaller fragments, leaving a CLIP peptide in the antigen binding grooves of the MHC class II molecule. _____ Alpha and beta chains of the MHC class II molecule assemble in the endoplasmic reticulum. _____ Peptides derived from endocytosed material bind to MHC class II complex.Explanation / Answer
(1) Alpha and beta chains of the MHC class II molecule assemble in the endoplasmic reticulum.
(2) Peptides derived from endocytosed material bind to MHC class II complex.
(3) MHC class II molecules intersect with the phagolysosomes, where peptides are degraded by enzymes into smaller peptide fragments.
(4) Invariant chain (Ii) binds to the MHC class II antigen-binding site to prevent premature binding.
(5) Proteolysis cleaves Ii into smaller fragment, leaving a CLIP peptide in the antigen-binding grooves of the MHC class II molecule.
(6) CLIP is released by HLA-DM binding.
(7) MHC class II molecules progress towards cell membrane in membrane-bound vesicles.
(8) Ii guides MHC class II molecule out of endoplasmic reticulum and into a vesicle.