Please give an explanation with your solution. I privided an intial structure th

Question

Please give an explanation with your solution. I privided an intial structure that needs to be amended. Apparently, the two changes we are trying to achieve throu synthesis are the creation of the unsaturated bond in the lower right of the molecule and changing the hydroxyl group to a methoxy group. Thank you for your time.

V) Methyl-dehydrolasiodiplodin (the configuration of the double bond is irrelevant) is a structural analog of a natural product (lasiodiplodin) OMe O: Meo Methyl-dehydrolasiodiplodin It exhibits a uniformly high activity against several human tumors e.g. lung, colon, melanoma, ovarian, renal, prostate and breast cancers, and is therefore of significant interest as a svnthetic target. 1) Provide your retrosynthetic analysis of this target. 2) Write a synthetic scheme corresponding to your retrosynthetic analysis, including possible reaction conditions

Explanation / Answer

Hydroxy to methoxy is single step reaction, but creation of double bond in structure that you provided is difficult.

You need to carry provision for double bond from initial stage.

I send you one research paper that might help you.

Journal of the Brazilian Chemical Society

Go through link-

http://www.scielo.br/scielo.php?pid=S0103-50532005000700020&script=sci_arttext&tlng=es

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