Problem 13.12 Part A Predict which one of the five steps of the -ketoglutarate d

Question

Problem 13.12

Part A

Predict which one of the five steps of the -ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions.

Predict which one of the five steps of the lpha-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions.

Step 1. Decarboxylation. Step 2. Oxidation of 4-carbon group, reduction of lipoamide disulfide. Step 3. Transacylation. Step 4. Dihydrolipoyl dehydrogenase. Step 5. FADH2 enzymatically reoxidized by NAD+ to form NADH .

Explanation / Answer

The reaction of -ketoglutarate dehydrogenase complex that is metabolically irreversible under physiological conditions is:

-ketoglutarate + NAD+ + CoA Succinyl CoA + CO2 + NADH

Hence based on the above information the option:

Step 1. Decarboxylation is correct as all decarboxylation are irreversible.

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