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Map Sapling Learning Gr Use the drop-down menus to identify which substances inh

ID: 266901 • Letter: M

Question

Map Sapling Learning Gr Use the drop-down menus to identify which substances inhibit the following glycolytic enzymes. Then choose the type of regulation each represents. Note that the enzyme used in step 1 varies, depending on the location in the body. Many of the products or proteins have abbreviations: G6P is glucose-6-phosphate, F6P is fructose-6-phosphate, and GKRP is glucokinase regulatory protein 0 Step 1 (most tissues): hexokinase glucose ATP Select answer O feedback control O zymogen ADP glucose-6-phosphate Th osteric control only 2 fructose-6-phosphate Step 1 (iver): glucokinase ATP O feedback control O zymogen O allosteric control only Select answer ADP fructose-1,6-bisphosphate dihydroxyacetoneglyceraldehyde phosphate 3-phosphate 5 Step 10: pyruvate kinase NAD HOPO3 NADH H+ Select answer O feedback control O zymogen O allosteric control only 1,3-bisphosphoglycerate ADP Previous Q Check Answer? Next Exit Hint

Explanation / Answer

1. If glucose -6-phosphate is accumalated in the cell, the enzyme hexokinase exhibits feedback regulation, till Glucose-6-phosphate is consumed.

2. Glucokinase is considered as allosteric enzyme which plays a major role in homeostasis of blood glucose. The enzyme glucokinase is indirectly regulated by allosteric effectors of glucokinase regulatory protein.

3. Pyruvate kinase is regulated by the allosteric effectors. Fructose 1-6-biphosphate serves as the allosteric effector of the enzyme pyruvate kinase.