IL Meaning of Graphics (75 pts) A. (15 Pts Total) melanoma cell melanoma cell me
ID: 3513869 • Letter: I
Question
IL Meaning of Graphics (75 pts) A. (15 Pts Total) melanoma cell melanoma cell melanocyte I keratinocyte fibroblast Endothelial cell 1. 3 Pts) The picture on the left is illustrating the attachment of a melanocyte to a keratinocyte. What cell type are these, or what kind of cell attachment is this uillustrating? 2. (3 Pts) The picture on the right is showing melanoma cells attached to an endothelial cells or to a fibroblast. What kind of cells are endothelial cells and fibroblasts? 3. (3 Pts) What key feature of cancer biology are these two pictures demonstrating? 4. (3 pts) How does this process contribute to cancer pathobiology? 5. (3 pts) What are E and N-
Explanation / Answer
1. 3 Pts) The picture on the left is illustrating the attachment of a melanocyte to a keratinocyte. What cell type are these, or what kind of cell attachment is this illustrating?
These cells are found in the epidermis. The melanocyte is responsible for giving color to the skin. This contact-dependent instruction is required for growth and phenotypic control of melanocytes by keratinocytes.
2. (3 Pts) The picture on the right is showing melanoma cells attached to an endothelial cell or to a fibroblast. What kind of cells are endothelial cells and fibroblasts?
A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.
3. (3 Pts) What key feature of cancer biology are these two pictures demonstrating?
Altered cell to cell communication. Malignant melanoma cells escape keratinocyte control and instead interact with fibroblasts and endothelial cells.This shift is associated with the switch of communication profile from E to N cadherin.
4. (3 pts) How does this process contribute to cancer pathobiology?
Altered cell to cell communication can lead to melanoma. This gives rise to new gap junction. THESE EvENTS ARE CRUCIAL TO ALLOW MELANOMA CELLS TO METASTASIZE.
5. (3 pts) What are E and N-]
They are E and N cadherins.