Map sapling earning Glycogen synthase catalyzes glycogen synthesis. Determine wh

Question

Map sapling earning Glycogen synthase catalyzes glycogen synthesis. Determine whether each of the following are associated with an increase or decrease in glycogen synthase activity X ncreased glycogen synthase activity Decreased glycogen synthase activity subunit dissociation of phosphorylation of CAMP-dependent glycogen synthase protein kinase, or PKA dephosphorylation (inactivation) phosphorylation of of phosphoprotein [synthase] phosphorylase phosphatase inhibitor (Pl1) kinase, or SPK inhibition of PP1 insulin

Explanation / Answer

Glycogen synthase (GS) is the key enzyme for the regulation process of glycogenesis.

Stimulation of glycogenesis

Insulin - Insulin increases the protein phosphatase 1 activity

Glucocorticoids increases activity of protein phosphatase 1 and increases the synthesis of glycogen synthase

Substrate glucose increased concentration increases synthesis

Inhibition of Glycogenesis

Increased concentration of glycogen inhibits glycogenesis -Feed back inhibition

Increased concentration of cyclic -AMP stimulates Inhibitor-1 to form active inhibitor-1-P, which in turn inhibits

protein phosphatase-1

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