Part A) Propose a solvent system for use with TLC to determine whether your prod

Question

Part A)

Propose a solvent system for use with TLC to determine whether your product is pure. Develop your TLC procedure to include implications for seperation as evidenced by Rf values

Part B)

The solubility of compound A in ethanol is 0.61 g per 100 mL at 0 C and 3.84 g per 100 mL at 65 C. What is the minimum amount of ethanol needed to recrystallize a 9.44 g sample of compound A? How much of ethanol is needed to recrystallize a 9.44 g sample of compound A? How much would be lost in the recrystallization and remain in the cold solvent? Show all work for full credit.

Explanation / Answer

PART A:Thin layer chromatography (TLC) is a useful technique for the separation and
identification of compounds in mixtures. TLC is used routinely to follow the progress of
reactions by monitoring the consumption of starting materials and the appearance of
products. Commercial applications of TLC include the analysis of urine for evidence of
"doping", the analysis of drugs to establish purity or identity of the components, and
analysis of foods to determine the presence of contaminants such as pesticides.

Repeat the experiment using some of the mixtures of methanol and
methylene chloride available in the lab, measure the Rf values on each occasion.
Keep trying mixtures until you have identified that which you think gives the best
results, i.e. the one which gives the best separation (resolution) of the three
materials. Keep in mind that if the three components are bunched together at the
top or bottom of the plate then they haven

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