Consider the following mutations and, for each, explain whether a) you expect it
ID: 181553 • Letter: C
Question
Consider the following mutations and, for each, explain whether
a) you expect it to be potentially promoting cancer AND
b) you expect it to be a dominant or recessive mutation.
Explanation / Answer
1. ANS:
If a mutation that destroys the active site of an enzyme, that kind of mutation should be present in recessive form, why because the function of the enzyme is lose. So this mutation WOULD NOT promote cancer. These kinds of mutations are unable to promote cell proliferation.
2. ANS: In this the function is lost, so this mutation is also belongs to recessive type. This mutation WOULD be promoted cancer. It is due to in the future cancer-promoting mutations may go unrepaired.
3. ANS:
The point mutation renders constitutively active one of the signaling proteins in the Ras pathway. This type of mutations are mostly belongs to dominant in nature. This mutation is capable to cell proliferation. So this type of mutation WOULD be cause cancer.
4. ANS:
The null mutation present in a gene encoding an apoptotic (apoptosis-promoting) protein. Apoptosis is a process of dead cell removing from the body. In this the function is lose, so it is also recessive. This type of cells WOULD promote cancer. In normal condition the cell undergoes into apoptosis.