Consider the following mutations and, for each, explain whether a) you expect it
ID: 53558 • Letter: C
Question
Consider the following mutations and, for each, explain whether
a) you expect it to be potentially promoting cancer AND
b) you expect it to be a dominant or recessive mutation.
i) A mutation that destroys the active site of an enzyme necessary to promote cell cycle
a)
b)
ii) A very premature STOP codon in a gene encoding a protein involved in the excision-repair mechanism
a)
b)
iii) A point mutation that renders constitutively active one of the signaling proteins in the Ras pathway
a)
b)
iv) A null mutation in a gene encoding an apoptotic (apoptosis-promoting) protein
a)
b)
Explanation / Answer
A mutation that destroys the active site of an enzyme necessary to promote cell cycle
It is a dominant or recessive mutation
A very premature STOP codon in a gene encoding a protein involved in the excision-repair mechanism
Dominant or Recessive mutation
A point mutation that renders constitutively active one of the signaling proteins in the Ras pathway
Potentially promoting cancer
A null mutation in a gene encoding an apoptotic (apoptosis-promoting) protein
Potentially promoting cancer